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Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
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The pathophysiology of pneumonia involves the following steps:
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Related Experiment Video

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Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation
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[Lamotrigine-induced pneumonitis].

Helle Dall Madsen1, Jesper Rømhild Davidsen

  • 1helle.madsen3@rsyd.dk.

Ugeskrift for Laeger
|December 15, 2016
PubMed
Summary

Lamotrigine, a medication for epilepsy and bipolar disorder, can cause lung inflammation (pneumonitis). Discontinuing lamotrigine improved a patient's breathing difficulties, highlighting the need to consider this side effect.

Area of Science:

  • Pulmonary Medicine
  • Clinical Pharmacology

Background:

  • Schizophrenia treatment often involves multiple medications.
  • Lamotrigine is a widely used anticonvulsant and mood stabilizer.

Observation:

  • A 28-year-old woman with schizophrenia presented with months of progressive dyspnea and oxygen dependency.
  • High-resolution computed tomography revealed ground glass opacities.
  • The patient had a history of long-term lamotrigine treatment.

Findings:

  • Tapering lamotrigine treatment led to clinical stabilization and resolution of dyspnea.
  • Lamotrigine-induced pneumonitis was suspected as the cause of the patient's respiratory symptoms.

Implications:

  • Clinicians should consider lamotrigine-induced pneumonitis in patients with unexplained progressive dyspnea.

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  • Prompt recognition and discontinuation of the offending drug are crucial for managing this adverse effect.