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Updated: Aug 11, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
[Acute cyanide poisoning in an infant]
A 9-month-old infant recovered from severe cyanide poisoning after accidental exposure to hydrocyanic acid. Prompt treatment with a methaemoglobin inducer and sodium thiosulphate was effective, though hypotonia lingered.
Area of Science:
- Toxicology
- Pediatrics
- Environmental Health
Background:
- Infants are vulnerable to environmental toxins.
- Cyanide poisoning can occur from unexpected sources, including building materials.
- Accidental hydrocyanic acid exposure poses a significant risk to child health.
Observation:
- A 9-month-old infant presented in a comatose state, with suspected cyanide poisoning.
- The infant's exposure occurred due to hydrocyanic acid desorption from building materials post-fumigation.
- Despite safety protocols, environmental toxin release posed a significant risk.
Findings:
- The infant received a combination of 4-dimethyl-aminophenol (a methaemoglobin inducer) and sodium thiosulphate.
- Supportive care was administered alongside the specific antidotes.
- Complete clinical recovery was achieved for the infant.
Implications:
- This case highlights the potential for delayed toxic effects from environmental fumigation.
- Early recognition and administration of specific antidotes are crucial for managing cyanide poisoning in infants.
- The successful outcome underscores the efficacy of methaemoglobin inducers and sodium thiosulphate in treating severe cyanide toxicity.
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