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Published on: February 18, 2015
Immunoregulation in Fungal Diseases.
Jonathan A Roussey1,2, Michal A Olszewski3,4,5, John J Osterholzer6,7,8
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA. jroussey@med.umich.edu.
This review explores immune system regulation during fungal infections, detailing key cells like dendritic cells and regulatory T cells. It highlights pathways such as interleukin-10 and programmed cell death 1, crucial for controlling fungal disease outcomes.
Area of Science:
- Immunology
- Mycology
Background:
- Host immune responses are critical for controlling fungal infections.
- Dysregulation of immune responses can lead to severe fungal diseases.
Approach:
- This review synthesizes current research on immune regulatory mechanisms in fungal infections.
- It focuses on key cellular players and signaling pathways.
- Specific examples of fungal pathogens are used for illustration.
Key Points:
- Dendritic cells and regulatory T cells play pivotal roles in antifungal immunity.
- Interleukin-10, PD-1, and CTLA-4 signaling pathways are central to immune regulation.
- Interactions between these cells and pathways determine infection outcomes.
Conclusions:
- Understanding these regulatory mechanisms is essential for developing effective antifungal therapies.
- Clinically relevant phenomena like protective tolerance and immune reconstitution inflammatory syndrome offer insights into fungal immunoregulation.
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