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Myoglobinuria exacerbates ischemic renal damage in the dog
A K Mandal1, J B Davis, R D Bell
1Division of Nephrology, VA Medical Center, Dayton, Ohio.
Nephron
|January 1, 1989
Summary
Intramuscular glycerol worsened ischemic acute renal failure in dogs. Higher glycerol concentrations (75%) led to severe acute tubular necrosis and increased mortality, indicating glycerol exacerbates kidney damage during ischemia.
Area of Science:
- Nephrology
- Toxicology
- Experimental Medicine
Background:
- Ischemic acute renal failure (ARF) is a critical condition.
- The role of exogenous substances in exacerbating ARF requires further investigation.
- Glycerol administration is common in some medical contexts.
Purpose of the Study:
- To investigate the effects of intramuscular glycerol on experimentally induced ischemic acute renal failure in dogs.
- To determine if glycerol concentration influences the severity of renal damage during ischemia.
Main Methods:
- Anesthetized dogs underwent bilateral renal artery obstruction (RAO) for 120 minutes.
- Groups received either RAO alone, RAO plus 50% glycerol, or RAO plus 75% glycerol.
- Control groups received glycerol without RAO.
- Renal histopathology and serum markers (creatinine, clearance, fractional excretion of sodium) were analyzed.
Main Results:
- Glycerol alone caused minimal renal histopathology.
- RAO dogs receiving 50% glycerol showed diffuse acute tubular necrosis (ATN).
- RAO dogs receiving 75% glycerol exhibited severe ATN and high mortality.
- Biochemical changes correlated with histopathological findings.
Conclusions:
- Intramuscular glycerol can significantly exacerbate renal damage in the presence of renal ischemia.
- Higher concentrations of glycerol (75%) are associated with more severe acute tubular necrosis and increased mortality.
- Myoglobinuria, even at sub-failure levels, interacts with renal ischemia to worsen kidney injury.