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[Association between IL-19 gene polymorphisms and hepatitis B virus susceptibility in children]

Jie Fan1, Li-Hong Mu, Li Zhou

  • 1School of Public Health and Management, Chongqing Medical University/Research Center for Medicine and Social Development/Innovation Center for Social Risk Governance in Health, Chongqing 400016, China. 1097123703@qq.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|December 16, 2016
PubMed

Insights

Single nucleotide polymorphisms (SNPs) in interleukin (IL)-19 may influence hepatitis B virus (HBV) infection susceptibility in children. Specific IL-19 SNPs were linked to increased risk of HBV infection and breakthrough infections in high-risk children.

Area of Science:

  • Immunogenetics
  • Hepatology
  • Pediatric Infectious Diseases

Background:

  • Hepatitis B virus (HBV) infection remains a significant global health concern, particularly in children.
  • Genetic factors, including single nucleotide polymorphisms (SNPs), may play a role in determining susceptibility to HBV infection.
  • Interleukin-19 (IL-19) is a cytokine involved in immune responses, and its genetic variations warrant investigation for potential links to HBV infection.

Purpose of the Study:

  • To investigate the association between specific SNPs of the IL-19 gene and the susceptibility to HBV infection in a pediatric population.
  • To explore whether IL-19 gene polymorphisms are correlated with the risk of developing hepatitis B in children.
  • To examine the potential role of IL-19 SNPs in breakthrough HBV infections among children born to HBV-positive mothers.

Main Methods:

  • A case-control study design was employed, involving 136 children with confirmed HBV infection (case group) and 297 healthy children without HBV infection (control group).
  • Polymerase Chain Reaction (PCR) and DNA sequencing techniques were utilized for accurate genotyping of IL-19 SNPs.
  • Statistical analyses were performed to compare genotype and allele frequencies between case and control groups, and within subgroups based on maternal HBV status.

Main Results:

  • Significant differences in genotype frequencies for IL-19 rs1798 were observed between children with and without HBV infection. The CG genotype of rs1798 was more prevalent in the HBV-infected group (p<0.05).
  • For IL-19 rs2243191, significant associations were found between genotype/allele frequencies and HBV infection status in children born to HBV-positive mothers.
  • Children with HBV infection exhibited higher proportions of TC and CC genotypes, as well as the C allele, for rs2243191 compared to non-infected children (p<0.05).

Conclusions:

  • The single nucleotide polymorphism rs1798 in the IL-19 gene may be associated with an increased susceptibility to hepatitis B infection in children.
  • The single nucleotide polymorphism rs2243191 in the IL-19 gene might be linked to the susceptibility of breakthrough HBV infections in high-risk pediatric populations.
  • These findings suggest that IL-19 gene variations could be potential genetic markers for HBV infection risk in children.
Abstract

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