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Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape

Xia Gao1, Jason W Locasale1

  • 1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.

Cell Metabolism
|December 16, 2016
PubMed

Insights

The tumor suppressor LKB1 influences cancer development by connecting cellular metabolism to epigenetic changes. This occurs via the LKB1/AMPK/mTOR signaling pathway, linking metabolism and epigenetics in oncogenesis.

Area of Science:

  • Cellular metabolism
  • Epigenetics
  • Oncogenesis

Background:

  • Intermediary metabolism impacts epigenetic modifications.
  • The role of metabolic-epigenetic interactions in cancer is not well understood.

Purpose of the Study:

  • To investigate how intermediary metabolism influences epigenetic status.
  • To explore the connection between metabolism, epigenetics, and oncogenesis.

Main Methods:

  • The study by Kottakis et al. (2016) in Nature investigated the LKB1 tumor suppressor gene.
  • Analysis of the LKB1/AMPK/mTOR signaling axis.

Main Results:

  • The LKB1 gene acts as a mediator between metabolic substrates and epigenetic alterations.
  • The LKB1/AMPK/mTOR pathway is implicated in this process.

Conclusions:

  • The tumor suppressor LKB1 plays a crucial role in linking intermediary metabolism to epigenetic regulation.
  • This interaction, mediated by the LKB1/AMPK/mTOR axis, is relevant to oncogenesis.
Keywords:
AMPKLKB1epigeneticsmTORmethylationone-carbon metabolismpancreas cancerpancreatic cancerserine

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