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Updated: Mar 10, 2026
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
Published on: May 21, 2020
Periosteum mechanobiology and mechanistic insights for regenerative medicine
Melissa L Knothe Tate1, Nicole Y C Yu1, Iman Jalilian1
1Graduate School of Biomedical Engineering, University of New South Wales , Sydney, NSW, Australia.
Abstract:
Periosteum is a smart mechanobiological material that serves as a habitat and delivery vehicle for stem cells as well as biological factors that modulate tissue genesis and healing. Periosteum's remarkable regenerative capacity has been harnessed clinically for over two hundred years. Scientific studies over the past decade have begun to decipher the mechanobiology of periosteum, which has a significant role in its regenerative capacity. This integrative review outlines recent mechanobiological insights that are key to modulating and translating periosteum and its resident stem cells in a regenerative medicine context.
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