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Pin1 Knockout Mice: A Model for the Study of Tau Pathology in Alzheimer's Disease
Asami Kondo1, Onder Albayram1, Xiao Zhen Zhou2
1Division of Translational Therapeutics, Department of Medicine and the Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle, Boston, MA, 02115, USA.
Abstract:
Pin1 knockout in mice causes age-dependent neuropathy characterized by motor and behavioral deficits, tau hyper phosphorylation, tau filament formation, and neuronal degradation. Here, we describe the methods with mouse behavior test, immunostaining, and immunoblotting to detect many aspects of neurodegeneration in Pin1 knockout mice.
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