Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

406
Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
406
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

443
Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
443
Design Example: Aggregate Gradation01:24

Design Example: Aggregate Gradation

355
The right type and quality of aggregates are crucial for concrete as they significantly influence its properties, mix proportions, and cost-effectiveness. If different sources are available for sand, the commonly used fine aggregate in concrete, the selection of sand is primarily based on its gradation.
The grading, or particle-size distribution, of sand is determined using sieve analysis, with standard sizes ranging from 150 μm to 10 mm (ASTM No. 100 sieve to 3⁄8 in. sieve). Sand is...
355
Compacting Factor test01:22

Compacting Factor test

662
The compacting factor test is a method used to assess the workability of concrete. It is  especially suitable for concrete mixes containing aggregates up to one and a half inches in size. This test involves specialized equipment consisting of two truncated cone-shaped hoppers and a cylinder, all with polished interior surfaces to minimize friction.
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
662

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of Predictive Statistical Model for Gaining Valuable Insights in Pharmaceutical Product Recalls.

AAPS PharmSciTech·2024
Same author

Current State of Minitablet Product Design: A Review.

Journal of pharmaceutical sciences·2024
Same author

Editorial: Improving Product Quality through Process and Materials Understanding.

Pharmaceutical research·2023
Same author

Assessing the Impact of Punch Geometries on Tablet Capping Using a Newly Proposed Capping Index.

Pharmaceutical research·2023
Same author

Optimized L-SNEDDS and spray-dried S-SNEDDS using a linked QbD-DM<sup>3</sup> rational design for model compound ketoprofen.

International journal of pharmaceutics·2022
Same author

Negative porosity issue in the Heckel analysis: A possible solution.

International journal of pharmaceutics·2022

Related Experiment Video

Updated: Mar 10, 2026

Method to Produce Durable Pellets at Lower Energy Consumption Using High Moisture Corn Stover and a Corn Starch Binder in a Flat Die Pellet Mill
08:52

Method to Produce Durable Pellets at Lower Energy Consumption Using High Moisture Corn Stover and a Corn Starch Binder in a Flat Die Pellet Mill

Published on: June 15, 2016

21.7K

Comparative binder efficiency modeling of dry granulation binders using roller compaction.

Anshul Gupte1, Michael DeHart1, William C Stagner2

  • 1a Mayne Pharma Inc , Greenville , NC , USA.

Drug Development and Industrial Pharmacy
|December 16, 2016
PubMed
Summary
This summary is machine-generated.

Coprocessed Avicel DG (ADG) and its physical blend (PADCP) showed no significant performance differences in roller compaction and tableting compared to a physical mixture of microcrystalline cellulose and Kollidon VA-64 Fine (KVA64). KVA64 demonstrated superior binding capabilities.

Keywords:
Avicel DGExcipientsKollidon VA-64analysis of variancecompressioncontinuous pharmaceutical processingdry granulationmultivariate analysispowder technologyprincipal component analysisprincipal component regressionroller compactionspray-dried and coprocessed excipientstableting

More Related Videos

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

15.2K
Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

11.2K

Related Experiment Videos

Last Updated: Mar 10, 2026

Method to Produce Durable Pellets at Lower Energy Consumption Using High Moisture Corn Stover and a Corn Starch Binder in a Flat Die Pellet Mill
08:52

Method to Produce Durable Pellets at Lower Energy Consumption Using High Moisture Corn Stover and a Corn Starch Binder in a Flat Die Pellet Mill

Published on: June 15, 2016

21.7K
Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

15.2K
Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

11.2K

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Roller compaction is a key process in pharmaceutical manufacturing for granule formation and tablet production.
  • Excipient properties significantly influence the outcome of roller compaction and subsequent tableting.
  • Coprocessed excipients are designed to offer improved functionality over physical mixtures.

Purpose of the Study:

  • To evaluate the impact of roller compaction parameters on the granule and tableting properties of coprocessed Avicel DG (ADG), its physical blend (PADCP), and a physical mixture of microcrystalline cellulose and Kollidon VA-64 Fine (KVA64).
  • To compare the performance of coprocessed ADG with its physical blend and a KVA64 physical mixture.

Main Methods:

  • A 3^3 full-factorial experimental design was employed to study the effects of roller force, roller gap, and roller speed.
  • Analysis of Variance (ANOVA) and multivariate methods, including Principal Component Analysis (PCA) and Principal Component Regression (PCR), were used for data analysis.
  • Key response parameters included granule-to-fines ratio, compressibility index, tablet thickness, friability, breaking force, and disintegration time.

Main Results:

  • PCA separated ADG and PADCP formulations from KVA64, indicating binder-dependent differences in granule and tableting properties.
  • ANOVA revealed no significant performance differences between ADG and PADCP, except for tablet thickness.
  • PCR showed that ADG and PADCP had a negative effect on granule-to-fines ratio, tablet thickness, breaking force, and disintegration time, while KVA64 had a positive effect.
  • The KVA64 physical mixture exhibited overall better performance and binding capability.

Conclusions:

  • There is no statistically significant performance advantage of coprocessed Avicel DG (ADG) over a physical mixture (PADCP) of its components.
  • The KVA64 physical mixture demonstrated superior performance in roller compaction and tableting compared to ADG and PADCP.
  • Binder selection is critical and influences the granule and tableting characteristics significantly.