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[Diffusion of ofloxacin in infected ascitic fluid]
J P Latrive1, J C Barbare, J P Darchis
1Service d'Hépatogastroentérologie, Centre Hospitalier de Compiègne, Compiègne.
Abstract:
The ofloxacin diffusion was investigated in 13 cirrhotic patients with spontaneous bacterial peritonitis. Plasma and ascitic samples were collected at times H1, H31 and H8 after a first dose of 200 mg per os, in these 13 patients, after 4.5 or 6 days of 200 mg per os each 8 hours in 9 out of them. After the first dose, the plasmatic and ascitic concentrations, measured by High Performance Liquid Chromatography (HPLC), were between 0 and 3.62 mg/l, 0 and 1.95 mg/l respectively. The steady state concentrations are higher than the MIC'S for the organisms most commonly involved, comparable in the plasma and the ascitic fluid is good and suggest the interest of its use in this indication.
Insights
This study evaluated ofloxacin levels in cirrhotic patients with spontaneous bacterial peritonitis. Ofloxacin concentrations in plasma and ascitic fluid suggest its effectiveness in treating this infection.
Area of Science:
- Pharmacokinetics
- Infectious Diseases
- Hepatology
Background:
- Spontaneous bacterial peritonitis (SBP) is a serious complication of cirrhosis.
- Effective antibiotic therapy is crucial for managing SBP.
Purpose of the Study:
- To investigate the diffusion and concentration of ofloxacin in plasma and ascitic fluid of cirrhotic patients with SBP.
- To assess the potential of ofloxacin for treating SBP.
Main Methods:
- 13 cirrhotic patients with SBP were enrolled.
- Plasma and ascitic fluid samples were collected at various time points after oral administration of ofloxacin (200 mg).
- High-Performance Liquid Chromatography (HPLC) was used to measure ofloxacin concentrations.
Main Results:
- Plasmatic concentrations ranged from 0 to 3.62 mg/l, and ascitic fluid concentrations ranged from 0 to 1.95 mg/l after the first dose.
- Steady-state concentrations were found to be higher than the Minimum Inhibitory Concentrations (MICs) for common causative organisms.
- Comparable drug levels were observed in both plasma and ascitic fluid.
Conclusions:
- Ofloxacin demonstrates good diffusion into the ascitic fluid.
- The achieved concentrations suggest that ofloxacin is a promising therapeutic option for spontaneous bacterial peritonitis in cirrhotic patients.