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Related Experiment Video

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Vascular Casting of Adult and Early Postnatal Mouse Lungs for Micro-CT Imaging
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A method for evaluating the murine pulmonary vasculature using micro-computed tomography.

Michael R Phillips1, Scott M Moore2, Mansi Shah1

  • 1Division of Pediatric Surgery, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

The Journal of Surgical Research
|December 17, 2016
PubMed
Summary

Researchers developed a new method to analyze mouse pulmonary vasculature using high-resolution CT scans. This technique allows detailed quantitative assessment of lung blood vessels in mouse models of disease.

Keywords:
Computed tomographyLung developmentPulmonary circulation

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Area of Science:

  • Pulmonary vascular research
  • Medical imaging techniques
  • Mouse models in cardiovascular research

Background:

  • Alterations in pulmonary vasculature are linked to significant mortality and morbidity.
  • Quantitative morphometry methods for lung arterial trees exist for larger animals but not mice.
  • A novel method for quantitative assessment of murine pulmonary arterial vasculature is presented.

Purpose of the Study:

  • To establish a method for quantitative assessment of pulmonary arterial vasculature in mice.
  • To enable detailed morphometric analysis of the murine pulmonary vascular tree.
  • To provide a tool for studying diseases affecting the pulmonary vasculature in mouse models.

Main Methods:

  • Pulmonary artery vascular trees were pressure perfused with radio-opaque casting material in mice at various ages.
  • Lungs were fixed and scanned using high-resolution (8-μm) specimen computed tomography.
  • Vessels were segmented and categorized by lumen diameter and branch generation.

Main Results:

  • High-resolution segmentation enabled detailed quantitation of pulmonary vascular morphometrics.
  • Postnatal lung development showed a progressive increase in small-vessel number.
  • Arterial branching complexity increased with postnatal development.

Conclusions:

  • The developed method allows quantitative analysis of pulmonary vasculature in mice.
  • This technique is valuable for evaluating mouse models of pulmonary vascular diseases.
  • Provides a robust tool for preclinical research in pulmonary vascular conditions.