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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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White Matter Microstructural Abnormalities in Type 2 Diabetes Mellitus: A Diffusional Kurtosis Imaging Analysis.
1From the Department of Radiology and Tianjin Key Laboratory of Functional Imaging (Y.X., Y.Z., W.Q., Q.Z.), Tianjin Medical University General Hospital, Tianjin, China.
AJNR. American Journal of Neuroradiology
|December 17, 2016
Summary
Type 2 diabetes mellitus is linked to white matter changes affecting cognition. Diffusional kurtosis imaging reveals these abnormalities, potentially serving as early markers for cognitive decline.
Area of Science:
- Neuroimaging
- Diabetology
- Neurology
Background:
- Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment.
- White matter (WM) microstructural abnormalities are implicated in T2DM-related cognitive decline.
- Diffusion Tensor Imaging (DTI) studies highlight the role of WM changes.
Purpose of the Study:
- Investigate WM microstructural alterations in T2DM patients using diffusional kurtosis imaging (DKI).
- Assess associations between DKI metrics and clinical/cognitive measures in T2DM.
- Explore DKI's potential for early detection of cognitive impairment.
Main Methods:
- DKI and cognitive assessments performed on 58 T2DM patients and 58 controls.
- Voxel-based and ROI-based intergroup comparisons of DKI metrics.
- Correlation analyses between DKI metrics and clinical/cognitive data, controlling for covariates.
Main Results:
- Significant differences in diffusion metrics observed in corpus callosum, frontal WM, temporal WM, external capsule, and pons.
- Abnormal kurtosis metrics found in the splenium of the corpus callosum and pons.
- Altered diffusion in right prefrontal WM correlated with disease duration and attention performance.
Conclusions:
- DKI provides additional insights into WM microstructural abnormalities in T2DM beyond conventional diffusion.
- WM microstructural abnormalities may precede cognitive decline in T2DM.
- DKI metrics show promise as neuroimaging markers for predicting early cognitive impairment in T2DM.
