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The new Bruch's membrane opening - minimum rim width classification improves optical coherence tomography specificity
Gema Rebolleda1, Alfonso Casado1, Noelia Oblanca1
1Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Clinical Ophthalmology (Auckland, N.Z.)
|December 17, 2016
Summary
Bruch's membrane opening - minimum rim width (BMO-MRW) analysis shows significantly lower false-positive rates than retinal nerve fiber layer (RNFL) thickness in healthy eyes with tilted optic discs.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Diagnostics
Background:
- Tilted optic discs can lead to misdiagnosis of glaucoma.
- Assessing diagnostic accuracy in eyes with tilted optic discs is crucial.
Purpose of the Study:
- Compare the diagnostic classification of Bruch's membrane opening - minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness.
- Evaluate false-positive rates in healthy eyes with tilted optic discs.
Main Methods:
- Fifty healthy eyes with tilted optic discs were scanned using Spectralis and Cirrus optical coherence tomography (OCT).
- Bruch's membrane opening - minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness were analyzed.
- False-positive rates and specificity were compared between BMO-MRW, RNFL, and ganglion cell analysis (GCA).
Main Results:
- BMO-MRW analysis yielded a significantly lower false-positive rate (8%) compared to Spectralis RNFL (62%) and Cirrus GCA (50%).
- Specificity was significantly higher for BMO-MRW than RNFL in eyes with low (89.7% vs 41.4%) and moderate myopia (95.2% vs 33.3%).
Conclusions:
- OCT-derived BMO-MRW analysis offers superior specificity compared to RNFL analysis in tilted discs, regardless of refractive error.
- BMO-MRW is more specific than GCA analysis in tilted discs with moderate myopia.
