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Published on: August 10, 2012
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An Inquiry-Based Approach to Study the Synapse: Student-Driven Experiments Using C. elegans.
1Department of Natural Sciences, Assumption College, Worcester, MA 10609.
Summary
This inquiry-based module trains undergraduates as scientists using the model organism Caenorhabditis elegans. Students investigate a "mystery mutant" to enhance scientific skills and knowledge retention.
Area of Science:
- Neuroscience
- Genetics
- Education
Background:
- Inquiry-based learning enhances knowledge retention and application.
- Undergraduate science education benefits from hands-on, research-driven modules.
Purpose of the Study:
- To describe an inquiry-based teaching module for undergraduates.
- To train students in scientific methodology using Caenorhabditis elegans.
- To challenge students to investigate a mutant with defective cholinergic synaptic transmission.
Main Methods:
- Students learn and practice research techniques with Caenorhabditis elegans.
- Students design and execute hypothesis-driven experiments to characterize a mystery mutant.
- Key assays include aldicarb and levamisole assays to study synaptic transmission.
Main Results:
- Students successfully designed, executed, and analyzed experiments.
- Collaborative work and communication of findings were integral.
- Students reported increased understanding and satisfaction from conducting self-designed research.
Conclusions:
- The module effectively trains undergraduates in scientific inquiry and research skills.
- Caenorhabditis elegans is an effective model organism for undergraduate research.
- The module can be adapted for various course structures and time constraints.
