[Experimental study of hemodynamic changes following superior mesenteric arterial injection of various contrast...

Following the superior mesenteric arterial injection of three contrast media, [38% Meg/Na Amidotrizoate, 76% Meg/Na Amidotrizoate, Iopamidol (370 mg l/ml)], and isotonic saline, we measured and analyzed the changes of superior mesenteric arterial blood flow rate for 10 minutes continuously in 6 dogs by means of electromagnetic flow meter. Blood volume change of superior mesenteric arterial blood flow was calculated by integration of blood flow. After injection of the agents, superior mesenteric arterial flow increased and returned to control level. The duration was influenced by the agent's osmolality. Therefore, volume change was analyzed because it is concurrent index of flow and duration. Correlation between volume change (increase) of superior mesenteric arterial blood flow and the agent's osmolality was shown. (r = 0.985, p less than 0.01). Increased blood volume of local arterial blood flow appears to be a desirable index for estimating vasodilatory effect of contrast media.