[Changes in hepatic circulation after hepatic arterial embolization--an analysis of factors affecting the development...

Forty six patients with follow up angiography after hepatic arterial embolization using gelatin sponge particles were analysed to evaluate the factors affecting development of intra- and extrahepatic collaterals. Significant correlation was demonstrated between the grade of embolization and the development of collaterals (p less than 0.001). Also there was significant correlation between development of collaterals and combined use of anticancer drugs with emboli (p less than 0.001). This suggests the possibility of endothelial damages of the arteries caused by anticancer drugs, which may enhance the permanent arterial occlusion and subsequent development of collaterals. No significant correlation was demonstrated between the numbers of embolization therapy and development of collaterals in this study.