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Absorption of Orally Administered Hyaluronan
Mamoru Kimura1,2, Takuya Maeshima1, Takumi Kubota1
11 R&D Division, Kewpie Corporation , Sengawa Kewport, Tokyo, Japan .
Journal of Medicinal Food
|December 17, 2016
Summary
Oral hyaluronan (HA) is broken down by gut bacteria into smaller oligosaccharides. These absorbed oligosaccharides are then distributed to tissues like the skin, supporting HA
Area of Science:
- Biochemistry
- Gastroenterology
- Dermatology
Background:
- Hyaluronan (HA) is a popular supplement, but its oral absorption is debated.
- Understanding HA's fate in the digestive system is crucial for its therapeutic use.
Purpose of the Study:
- To investigate the degradation and absorption of orally administered hyaluronan in the intestine.
- To examine HA excretion, intestinal degradation, large intestine absorption, and tissue translocation.
Main Methods:
- Oral administration of high molecular weight HA (300 kDa) to rats.
- Analysis of HA in feces, cecal content, gastric and intestinal juices.
- In vitro studies using excised large intestine sacs.
- Measurement of HA distribution in rat tissues, specifically skin.
Main Results:
- Orally administered HA was not detected in rat feces.
- HA was degraded by cecal contents, but not by artificial gastric or intestinal juices.
- Oligosaccharide HA fragments permeated excised large intestine sacs.
- HA molecules were found in rat skin after oral administration of high molecular weight HA.
Conclusions:
- Oral HA is degraded into oligosaccharides by intestinal bacteria.
- Oligosaccharide HA is absorbed through the large intestine.
- Absorbed HA is distributed to various tissues, including the skin.
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