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Published on: October 8, 2016
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Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting
Brian C Palmer1, Lisa A DeLouise2,3,4
1Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. Brian_Palmer@URMC.Rochester.edu.
Molecules (Basel, Switzerland)
|December 17, 2016
Summary
Nanoparticle technology enhances transdermal drug delivery for larger molecules and vaccines, offering potential for new treatments. Further research into nanocarrier safety is ongoing.
Area of Science:
- Pharmaceutical Sciences
- Biotechnology
- Dermatology
Background:
- Transdermal drug delivery systems (e.g., patches, creams) currently excel with small, lipophilic drugs.
- Limitations exist for delivering larger, hydrophilic molecules and macromolecules via transdermal routes.
- Existing methods struggle to effectively deliver therapeutics for disease treatment and vaccination.
Purpose of the Study:
- To review current nanoparticle skin delivery systems.
- To explore enhancing skin penetration of large, hydrophilic drugs and macromolecules.
- To focus on nanoparticle applications for targeting skin diseases.
Main Methods:
- Review of existing literature on nanocarrier-based transdermal delivery.
- Analysis of lipid, metal, and polymer-based nanocarriers for skin penetration.
- Examination of in vivo studies demonstrating nanocarrier efficacy.
Main Results:
- Nanocarriers effectively increase skin penetration of drugs and vaccines.
- Nanoparticle systems offer controlled drug release capabilities.
- Targeted delivery of therapeutics to specific skin areas is achievable with nanocarriers.
Conclusions:
- Nanocarrier technology shows significant potential to broaden transdermal administration for diverse therapeutics.
- Further investigation into the safety of nanocarriers is crucial for clinical translation.
- Nanoparticle delivery systems are promising for treating various skin diseases.
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