Upper Eyelid Response to Topical 0.5% Apraclonidine
Christopher A Kirkpatrick1, Erin M Shriver1, Thomas J E Clark1
1Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, and Veteran's Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, Iowa, U.S.A.
Ophthalmic Plastic and Reconstructive Surgery
|December 17, 2016
Summary
Topical apraclonidine slightly elevates the upper eyelid in most individuals. This effect suggests potential use for treating mild eyelid drooping (ptosis) or asymmetry.
Area of Science:
- Ophthalmology
- Oculoplastics
Background:
- Upper eyelid position is crucial for visual function and aesthetics.
- Ptosis and eyelid retraction can cause functional and cosmetic concerns.
Purpose of the Study:
- To evaluate the effect of topical 0.5% apraclonidine on upper eyelid position in normal subjects.
- To quantify changes in the marginal reflex distance 1 (MRD1) after apraclonidine administration.
Main Methods:
- 100 normal subjects received one dose of topical 0.5% apraclonidine in each eye.
- Digital photographs were taken at baseline, 30, and 45 minutes post-instillation.
- Image analysis was used to measure the MRD1, with the horizontal corneal diameter as a scale.
Main Results:
- A mean increase in MRD1 of +0.70 mm at 30 minutes and +0.68 mm at 45 minutes was observed.
- 90.5% of eyelids showed an increased MRD1 at 30 minutes.
- 85% of subjects experienced a bilateral increase in MRD1.
Conclusions:
- Topical apraclonidine demonstrates a consistent, albeit small, upper eyelid elevating effect.
- It may serve as an off-label treatment for mild ptosis or eyelid asymmetry.
- Consideration for contralateral eye use in cases of eyelid retraction is suggested.
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