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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Mar 10, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Cutaneous lymphomas with a panniculitic presentation.

Rein Willemze1

  • 1Dept. of Dermatology, B1-Q-93, Leiden University Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

Seminars in Diagnostic Pathology
|December 18, 2016
PubMed
Summary

Subcutaneous panniculitis-like T-cell lymphoma and primary cutaneous gamma/delta T-cell lymphoma are common skin cancers presenting with fat inflammation. This review details their features and diagnostic criteria to distinguish them from other conditions.

Keywords:
Cutaneous T-cell lymphomaLupus panniculitisPrimary cutaneous gamma-delta T-cell lymphomaSubcutaneous panniculitis-like T-cell lymphoma

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Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Cutaneous T-cell lymphomas (CTCLs) can present with panniculitis-like lesions.
  • Subcutaneous panniculitis-like T-cell lymphoma (SPTL) and primary cutaneous gamma/delta T-cell lymphoma (PCGD-TCL) are the most frequent CTCL subtypes with this presentation.

Purpose of the Study:

  • To review the characteristic clinical, histological, and immunophenotypical features of SPTL and PCGD-TCL.
  • To discuss criteria for differentiating these lymphomas from benign and malignant lymphoproliferations with similar panniculitic presentations.

Main Methods:

  • Literature review of clinical, histological, and immunophenotypical data.
  • Comparative analysis of diagnostic features.

Main Results:

  • SPTL and PCGD-TCL exhibit distinct, yet sometimes overlapping, features.
  • Key differentiating criteria involve specific immunophenotypic markers and histological patterns.

Conclusions:

  • Accurate diagnosis of SPTL and PCGD-TCL relies on integrating clinical, histological, and immunophenotypic findings.
  • Distinguishing these lymphomas from other panniculitis-like lesions is crucial for appropriate patient management.