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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Cutaneous marginal zone lymphomas.

Steven H Swerdlow1

  • 1Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, UPMC-Presbyterian, G-335, 200 Lothrop Street, Pittsburgh, PA 15213.

Seminars in Diagnostic Pathology
|December 18, 2016
PubMed
Summary
This summary is machine-generated.

Primary cutaneous marginal zone lymphoma (CMZL) has two types: class-switched and IgM+. The indolent nature of class-switched CMZL raises questions about its classification as overt lymphoma.

Keywords:
B-cell lymphomaIgG4MALT lymphomaPrimary cutaneous marginal zone lymphomaSkin

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Area of Science:

  • Hematology
  • Dermatology
  • Oncology

Background:

  • Primary cutaneous marginal zone lymphoma (CMZL) is a significant B-cell skin lymphoma.
  • Two distinct subtypes exist: class-switched CMZL and IgM+ CMZL.
  • Class-switched CMZL is more prevalent than the IgM+ variant.

Purpose of the Study:

  • To review the classification and characteristics of primary cutaneous marginal zone lymphoma.
  • To discuss the indolent nature of class-switched CMZL.
  • To explore the debate regarding the classification of class-switched CMZL as overt lymphoma.

Main Methods:

  • Literature review
  • Comparative analysis of CMZL subtypes
  • Discussion of clinical features and classification criteria

Main Results:

  • Class-switched CMZL is the more common subtype.
  • IgM+ CMZL is a less frequently observed subtype.
  • The clinical course of class-switched CMZL is notably indolent, distinct from other MALT lymphomas.

Conclusions:

  • The indolent behavior of class-switched CMZL challenges its categorization as a typical overt lymphoma.
  • Further consideration is warranted for the classification of class-switched CMZL.
  • Distinguishing between CMZL subtypes is crucial for understanding disease behavior.