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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Acute Coronary Syndrome I: Introduction01:30

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

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Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Related Experiment Video

Updated: Mar 10, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

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Falsely elevated troponin: rare occurrence or future problem.

James Nguyen1, Rosy Thachil2, Neil Vyas3

  • 1Department of Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Queens, NY, USA; james.nguyen@mssm.edu.

Journal of Community Hospital Internal Medicine Perspectives
|December 18, 2016
PubMed
Summary
This summary is machine-generated.

Elevated cardiac troponin (cTn) levels can indicate heart damage but may also yield false positives due to assay interference. This case highlights the importance of considering non-cardiac causes and assay limitations when interpreting cTn results.

Keywords:
CK-MBchest painfalse immunoassayfalse positivemyocardial infarctionthree-site immunoassaytroponintwo-site immunoasay

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Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
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Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
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Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

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Area of Science:

  • Cardiology
  • Clinical Chemistry
  • Laboratory Medicine

Background:

  • Cardiac troponins (cTn) are established biomarkers for diagnosing acute myocardial infarction (AMI).
  • Elevated cTn levels are crucial for early AMI diagnosis and improved patient outcomes.
  • Assay interference can lead to inaccurate cTn results, complicating diagnosis.

Observation:

  • A patient presented with symptoms suggestive of cardiac events, exhibiting elevated troponin levels over several years.
  • Despite elevated troponin, cardiac evaluations including catheterization and CT scans revealed no obstructive coronary artery disease.
  • Further investigation, including sample dilution and testing at a different facility, indicated falsely elevated troponin levels.

Findings:

  • The case demonstrates a scenario of persistently elevated troponin levels in the absence of clinical or diagnostic evidence of myocardial infarction.
  • Interference in troponin immunoassays, potentially due to various factors, can lead to false-positive results.
  • Confirmation of false elevation was achieved by comparing results from different immunoassay methods.

Implications:

  • Clinicians must consider assay interference and non-AMI etiologies when interpreting elevated troponin levels, especially in ambiguous cases.
  • The increasing use of immunotherapies and radiolabeled antibodies may increase the prevalence of troponin assay interference.
  • A high index of suspicion for false-positive troponin results is essential for accurate patient management and to avoid unnecessary interventions.