Amiloride reduces maternofetal clearance of sodium across the near-term rat placenta

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D E Atkinson1, C P Sibley, N R Robinson

  • 1Department of Child Health, St Mary's Hospital, University of Manchester.

Quarterly Journal of Experimental Physiology (Cambridge, England)
|July 1, 1989
PubMed

The effect of amiloride on unidirectional maternofetal clearance across the perfused placenta has been studied in rats at 21 days gestation. A bolus dose of 1 mg kg-1 followed by an infusion of 0.6 mg h-1 into the maternal circulation caused a significant (P less than 0.02) decrease in 22Na clearance by 8%, whilst having no effect on the clearance of 51Cr-EDTA; a ten times higher dose of amiloride (10 mg kg-1, 6 mg h-1) did not reduce 22Na clearance further. Similar administration of an equivalent volume of saline to control animals showed no effect on either Na+ or Cr-EDTA clearances.

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