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Updated: Mar 10, 2026
Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Mesoporous hydroxyapatite nanoparticles hydrothermally synthesized in aqueous solution with hexametaphosphate and tea
Huan Zhou1, Mengmeng Yang2, Saisai Hou3
1Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China; International Research Centre for Translational Orthopedics (IRCTO), Suzhou, Jiangsu 215006, China.
Abstract:
Mesoporous hydroxyapatite (HA) nanoparticles with high surface area have been widely investigated for drug delivery. Herein we report a facile and simple strategy for the preparation of such materials using hexametaphosphate salt as inorganic phosphorus source. In the hydrothermal processing, hexametaphosphate plays an important role in the formation of mesoporous structure. The as-prepared mesoporous HA nanoparticles can be candidates for pH-responsive anticancer drug delivery by using doxorubicin (Dox) as a model drug. Furthermore, modification of these mesoporous HA nanoparticles using tea polyphenols is attempted. The presence of tea polyphenols in the HA synthesis processing result in mesoporous HA nanoparticles with tailored morphology and properties, making them more pH-sensitive for drug delivery. Both hexametaphosphate and tea polyphenols can be potential chemical sources in synthesizing mesoporous HA.
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