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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Distribution of ABO Blood Groups and Coronary Artery Calcium
Yao Wang1, Bing-Yang Zhou1, Cheng-Gang Zhu1
1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Insights
Individuals with blood type A have a higher risk of developing coronary artery calcium (CAC), a marker for cardiovascular disease. Blood type O is associated with a lower risk.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Epidemiology
Background:
- ABO blood groups are linked to cardiovascular diseases.
- The relationship between ABO blood groups and coronary artery calcium (CAC) remains unclear.
Purpose of the Study:
- To investigate the association between ABO blood group and the presence of coronary artery calcium (CAC).
Main Methods:
- 301 patients with computed tomography-assessed coronary artery calcium scores (CACS) were analyzed.
- Patients were categorized into groups with (CACS>0) and without (CACS=0) calcification.
- ABO blood group distribution was compared between the groups.
Main Results:
- Blood type A was more prevalent, and blood type O was less prevalent in the calcified group.
- Univariate analysis indicated positive correlations of blood type A with CAC and inverse association with blood type O.
- Multivariate analysis confirmed blood type A as an independent risk factor for CAC (OR: 2.217, P=0.006).
Conclusions:
- Blood type A is identified as a novel, independent risk marker for coronary artery calcium (CAC).
Background:
ABO blood groups have been confirmed to be associated with cardiovascular diseases such as coronary artery disease. However, whether ABO blood group is correlated with coronary artery calcium (CAC) is still unknown.
Method:
301 patients with coronary artery calcium score (CACS) assessed by computed tomography were consecutively enrolled and divided into two groups: with calcium group (CACS>0, n=104) and without calcium group (CACS=0, n=197). Distribution of ABO blood groups was evaluated between the two groups.
Results:
The percentage of A blood type was significantly higher (p=0.008) and O blood type was significantly lower (p=0.037) in the calcium group. Univariate regression analysis showed that age, total cholesterol, low density lipoprotein cholesterol, high-sensitivity C-reactive protein, A blood type were positively correlated with CAC, and O blood type was inversely associated with CAC. Multivariate regression analysis showed that A blood type was independently associated with CAC (odds ratio: 2.217, 95% confidence interval: 1.260-3.900, p=0.006) even after further adjustment for variables that were clearly different between the two groups.
Conclusions:
Our data has suggested for the first time that A blood type was an independent risk marker for CAC.
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