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Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients.

Hanna Myśliwiec1, Anna Baran2, Ewa Harasim-Symbor3

  • 1Department of Dermatology and Venereology, Medical University of Bialystok, Żurawia Str. 14, 15-540, Bialystok, Poland. hanna.mysliwiec@gmail.com.

Archives of Dermatological Research
|December 19, 2016
PubMed
Summary
This summary is machine-generated.

Psoriasis patients show altered sphingolipid levels, with decreased ceramides (CER) and increased sphingosine-1-phosphate (S1P). These changes may indicate altered skin metabolism and are linked to psoriatic arthritis.

Keywords:
CeramidePsoriasisPsoriatic arthritisSphingolipidsSphingosine-1-phosphate

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Area of Science:

  • Dermatology
  • Biochemistry
  • Immunology

Background:

  • Psoriasis involves keratinocyte abnormalities and is associated with lipid profile disturbances and metabolic syndrome.
  • Sphingolipids, including ceramides (CER) and sphingosine-1-phosphate (S1P), are key signaling molecules regulating cell behavior and immune responses.
  • The precise mechanisms linking psoriasis to metabolic alterations, particularly concerning sphingolipids, remain unclear.

Purpose of the Study:

  • To investigate circulating ceramide (CER) and sphingosine-1-phosphate (S1P) levels in plaque-type psoriasis patients.
  • To assess the association of these sphingolipid levels with disease activity, inflammatory markers, metabolic parameters, and psoriatic comorbidities.
  • To explore potential differences in sphingolipid profiles between psoriasis patients with and without psoriatic arthritis.

Main Methods:

  • Serum samples were collected from 85 patients with active plaque-type psoriasis and 32 healthy controls before treatment.
  • Quantification of total serum ceramide (CER) and sphingosine-1-phosphate (S1P) concentrations.
  • Analysis included Psoriasis Area and Severity Index (PASI), Body Mass Index (BMI), inflammatory markers, lipid profiles, and assessment of psoriatic comorbidities.

Main Results:

  • Psoriatic patients exhibited significantly decreased total serum CER levels (p=0.02) and significantly increased S1P levels (p=0.002) compared to healthy controls.
  • No significant correlations were found between sphingolipid levels and psoriasis disease activity or general inflammation markers.
  • Patients with psoriatic arthritis demonstrated significantly higher total CER concentrations compared to psoriasis patients with skin involvement only.

Conclusions:

  • Serum sphingolipid disturbances, characterized by reduced CER and elevated S1P, are present in plaque-type psoriasis patients.
  • These alterations may reflect changes in epidermal sphingolipid metabolism and composition.
  • Elevated CER levels in psoriatic arthritis patients could serve as a potential biomarker for the condition and indicate an increased risk for metabolic and cardiovascular diseases.