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γ-Cyclodextrin.

Phennapha Saokham¹, Thorsteinn Loftsson¹

¹Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland.

International Journal of Pharmaceutics

|December 20, 2016

Summary

This summary is machine-generated.

Gamma-cyclodextrin (γCD), a starch derivative, offers superior solubility and a favorable safety profile compared to other cyclodextrins. Its negligible bioavailability and excretion make it a safe excipient for pharmaceutical and food applications.

Keywords:

ADME Aggregation Complexing agent Inclusion complex Solubilization γ-Cyclodextrin

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Area of Science:

Biochemistry and Pharmaceutical Sciences
Food Science and Technology

Background:

Gamma-cyclodextrin (γCD) is a cyclic oligosaccharide derived from starch.
It functions as a solubilizing agent and stabilizer in pharmaceutical and food products.
γCD exhibits a large hydrophobic cavity, high water solubility, and a favorable toxicological profile compared to αCD and βCD.

Purpose of the Study:

To review the production, physiochemical properties, pharmacokinetics, and toxicity of γCD and its derivatives.
To discuss the applications of γCD in various industries.
To explore the aggregation behavior of γCD in aqueous media.

Main Methods:

Literature review focusing on scientific publications related to γCD.
Analysis of physiochemical properties, pharmacokinetic data, and toxicological studies.
Discussion of reported applications and aggregation phenomena.

Main Results:

γCD is poorly bioavailable due to rapid gastrointestinal digestion and metabolism by α-amylase.
It is readily excreted unchanged in urine after parenteral administration.
γCD forms water-soluble inclusion complexes with poorly soluble compounds.

Conclusions:

γCD possesses advantageous properties, including high solubility and a favorable safety profile, making it suitable for pharmaceutical and food applications.
Its negligible bioavailability and rapid excretion contribute to its safety.
Further research into its derivatives and aggregation behavior is warranted.