Online sensing of palladium in flowing streams
Xiaodong Bu1, Michael Williams1, Junyong Jo1
1Department of Process Research and Development, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA. christopher_welch@merck.com xiaodong_bu@merck.com.
Abstract:
Rapid palladium (Pd) catalyzed deallylation of an uncoloured reagent within a flowing stream affords a dose dependent colour formation that can be used for convenient online analysis of trace levels of Pd contamination using a modified HPLC instrument. An application to the online sensing of Pd breakthrough from a flow through Pd adsorption cartridge is described. An alternative configuration of the instrumentation allows the rapid (<1 min) and accurate measurement of Pd levels within samples injected via a conventional HPLC autosampler.
