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Long noncoding RNAs in the p53 network.

Ritu Chaudhary1, Ashish Lal1

  • 1Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.

Wiley Interdisciplinary Reviews. RNA
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Summary
This summary is machine-generated.

The tumor suppressor protein p53 regulates long noncoding RNAs (lncRNAs) that influence cellular stress responses. This review explores how p53-controlled lncRNAs contribute to p53

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The tumor suppressor protein p53 is a critical regulator activated by cellular stresses like DNA damage.
  • p53 acts as a transcription factor, controlling the expression of numerous genes, including protein-coding genes, microRNAs (miRNAs), and long noncoding RNAs (lncRNAs).
  • The roles of p53-regulated protein-coding genes and miRNAs are well-established, but the functions of p53-regulated lncRNAs are emerging.

Purpose of the Study:

  • To review recent findings on long noncoding RNAs (lncRNAs) regulated by the tumor suppressor p53.
  • To elucidate the physiological functions and molecular mechanisms of p53-regulated lncRNAs.
  • To understand how these lncRNAs contribute to the biological outcomes following p53 activation.

Main Methods:

  • Literature review of recent studies on p53 and lncRNA interactions.
  • Analysis of molecular mechanisms underlying p53-lncRNA regulation.
  • Synthesis of data on the biological impact of p53-regulated lncRNAs.

Main Results:

  • Identified numerous lncRNAs directly or indirectly regulated by p53.
  • Highlighted the emerging understanding of the functional roles of these p53-regulated lncRNAs.
  • Demonstrated the contribution of these lncRNAs to the cellular responses mediated by p53.

Conclusions:

  • p53-regulated lncRNAs play significant roles in the biological consequences of p53 activation.
  • Further research into these lncRNAs is crucial for understanding p53's tumor-suppressive functions.
  • This review consolidates current knowledge and points to future research directions in the field.