Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

7.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
7.5K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

12.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.4K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

6.1K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
6.1K
Abnormal Proliferation02:23

Abnormal Proliferation

4.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The enigma of the RING-UIM E3 ligases: its transformative impact on cancer research.

Journal of translational medicine·2025
Same author

Cytogenetic and Molecular Genetic Driven Prediction of Response to First-Treatment and Prognosis in Acute Myeloid Leukemia: A Retrospective Cohort Study.

Genes, chromosomes & cancer·2025
Same author

Gene Mutation Characteristics and Prognostic Significance in Acute Myeloid Leukemia Patients From Northeast China.

Human mutation·2025
Same author

Functional Landscape of hnRNPA3 in Disease Pathogenesis.

Wiley interdisciplinary reviews. RNA·2025
Same author

New advances in the role of JAK2 V617F mutation in myeloproliferative neoplasms.

Cancer·2024
Same author

A novel upregulated LncRNA-AC026150.8 promotes chemo-resistance and predicts poor prognosis in acute myeloid leukemia.

Cancer medicine·2021
Same journal

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications.

Wiley interdisciplinary reviews. RNA·2026
Same journal

Exploring New Frontiers in Bone Metabolism: Role and Potential of lncRNA DANCR.

Wiley interdisciplinary reviews. RNA·2026
Same journal

Functional Inclusion of RNA Biology in the Tethered Extracellular Matrix.

Wiley interdisciplinary reviews. RNA·2026
Same journal

Structural and Functional Diversity of RNA-Containing Toxin-Antitoxin Systems.

Wiley interdisciplinary reviews. RNA·2026
Same journal

Promoter-Targeting RNA Technologies: An Epigenetic Strategy for Gene Activation and Gene Silencing.

Wiley interdisciplinary reviews. RNA·2026
Same journal

Therapeutic Prospects of Artificially Synthesized Circular RNA.

Wiley interdisciplinary reviews. RNA·2026
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.3K

LncRNA PCAT18: Roles and Mechanisms in Human Cancers.

Xiaohui Wang1, Henan Zhang1, Fang Chen1

  • 1Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.

Wiley Interdisciplinary Reviews. RNA
|April 26, 2026
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are key in cancer. This review focuses on PCAT18, a lncRNA found to be highly expressed in prostate cancer and other malignancies, exploring its role in various cancers.

Keywords:
LncRNAPCAT18biomarkercancertargeted therapy

More Related Videos

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

27.7K

Related Experiment Videos

Last Updated: Apr 28, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.3K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

27.7K

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators in biological processes.
  • Dysregulation of lncRNAs is implicated in carcinogenesis, affecting cancer cell proliferation, apoptosis, invasion, metastasis, and immune evasion.
  • Prostate-specific lncRNA 18 (PCAT18) is an androgen-regulated gene significantly upregulated in prostate cancer (PCa).

Purpose of the Study:

  • To review the molecular mechanisms and clinical significance of PCAT18 in various types of cancer.
  • To consolidate current understanding of PCAT18's regulatory functions in oncogenesis.

Main Methods:

  • Literature review of studies investigating PCAT18.
  • Analysis of molecular mechanisms and clinical data related to PCAT18 expression and function in cancer.

Main Results:

  • PCAT18 is identified as a regulatory molecule in multiple cancers, including PCa, lung cancer, breast cancer, digestive cancers, and leukemia.
  • PCAT18 exhibits significant upregulation in these malignancies, suggesting a role in tumor development and progression.

Conclusions:

  • PCAT18 plays a critical role in the molecular pathogenesis of various cancers.
  • Further research into PCAT18's mechanisms and clinical utility may offer new therapeutic strategies for cancer treatment.