Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testing for central mixtures of compartment model parameters.

D Zelterman1

  • 1Department of Mathematics and Statistics, State University of New York, Albany 12222.

Statistics in Medicine
|August 1, 1989
PubMed
Summary

This study introduces new statistical methods for analyzing one compartment models, focusing on parameter mixtures rather than comparing different models. These techniques are applied to blood flow and vanadium depuration data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.

Nature communications·2018
Same author

A KRAS variant is a biomarker of poor outcome, platinum chemotherapy resistance and a potential target for therapy in ovarian cancer.

Oncogene·2011
Same author

WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A.

Journal of thrombosis and haemostasis : JTH·2010
Same author

Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.

Journal of neurophysiology·2009
Same author

The incidence and risk factors associated with postoperative delirium in geriatric patients undergoing surgery for suspected gynecologic malignancies.

Gynecologic oncology·2008

Area of Science:

  • Pharmacokinetics and Pharmacodynamics
  • Biophysical Chemistry
  • Statistical Modeling

Background:

  • The one compartment model is a standard pharmacokinetic model.
  • Comparing one and two compartment models is a common approach.
  • Limitations exist in directly comparing different compartment models.

Purpose of the Study:

  • To propose and derive statistics for testing mixtures of parameters within a one compartment model.
  • To offer an alternative to comparing one and two compartment models.
  • To apply novel statistical methods to real-world biological data.

Main Methods:

  • Derivation of statistical tests for parameter mixtures (beta, gamma) in the one compartment model.
  • Application of derived statistics to hydrogen clearance data for blood flow measurement.

Related Experiment Videos

  • Utilizing the methods on vanadium depuration data.

    • Main Results:

    • Developed novel statistical methodologies for analyzing one compartment models.
    • Successfully applied the methods to hydrogen clearance and vanadium depuration datasets.
    • Demonstrated the utility of parameter mixture testing as an alternative to model comparison.

    Conclusions:

    • The proposed statistical methods provide a viable alternative for analyzing complex pharmacokinetic data.
    • Parameter mixture testing within a single model offers valuable insights.
    • The methods are applicable to diverse biological systems, including blood flow and toxicokinetics.