Related Experiment Video
Updated: Mar 9, 2026
15:48
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
Published on: December 15, 2014
23.4K
Diffusion Tensor Imaging for Evaluating Biliary Atresia in Infants and Neonates.
Bo Liu1, Jinhua Cai1, Jin Zhu2
1Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Plos One
|December 20, 2016
Summary
Diffusion tensor imaging (DTI) shows promise in diagnosing biliary atresia (BA) in infants. Liver apparent diffusion coefficient (ADC) measured by DTI can help differentiate BA from other conditions and detect fibrosis.
Area of Science:
- Medical Imaging
- Hepatology
- Pediatric Radiology
Background:
- Diffusion tensor imaging (DTI) shows potential for evaluating liver disorders.
- Limited research exists on DTI's application in diagnosing biliary atresia (BA).
Purpose of the Study:
- To assess the diagnostic value of liver apparent diffusion coefficient (ADC) and fractional anisotropy (FA) using DTI for biliary atresia (BA) in neonates and infants.
Main Methods:
- Fifty-nine jaundiced infants underwent DTI with b factors of 0 and 1000 s/mm2.
- Liver fibrosis was graded (F0-F4) based on pathological findings in the BA group.
- Statistical analyses determined DTI's diagnostic accuracy for BA.
Main Results:
- The BA group exhibited significantly lower liver ADC values compared to the non-BA group (P<0.001).
- ADC demonstrated a diagnostic accuracy of 75% sensitivity and 81.5% specificity for differentiating BA.
- Liver ADC correlated with fibrosis stage, being higher in F0 than in advanced stages (F1-F4).
Conclusions:
- Hepatic ADC measured by DTI serves as a valuable adjunct for noninvasive differential diagnosis of BA.
- DTI-based ADC aids in detecting liver fibrosis but cannot differentiate between various fibrotic grades.
