Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

80
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
80

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bidirectional associations between cannabis use, oddball performance and P3 event-related potential.

medRxiv : the preprint server for health sciences·2026
Same author

Lifespan Trajectories of Resting State EEG power.

bioRxiv : the preprint server for biology·2026
Same author

Network and receptor architectures shape brain morphometry in addiction.

medRxiv : the preprint server for health sciences·2026
Same author

The 10-year stability of three subscale scores of the Self-Report of the Effects of Alcohol measure and their relationship to changes in drinking quantities over the same period.

Alcohol, clinical & experimental research·2026
Same author

Perceived partner substance use, genetic predispositions, and their associations with problematic alcohol use, emotional well-being, and relationship quality.

Psychological medicine·2026
Same author

Uncovering NMDA receptor-mediated high firing activity in excitatory human neurons.

iScience·2026

Related Experiment Video

Updated: Mar 9, 2026

Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG
09:35

Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG

Published on: March 10, 2017

9.7K

A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.

Chella Kamarajan1, Ashwini K Pandey1, David B Chorlian1

  • 1Henri Begleiter Neurodynamics Lab, SUNY Downstate Medical Center, Brooklyn, NY, USA.

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
|December 21, 2016
PubMed
Summary

Genetic variations in the KCNJ6 gene influence theta event-related oscillations (EROs) during reward processing. This suggests a genetic impact on neuronal circuits involved in evaluating gains and losses.

Keywords:
AlcoholismCOGAEvent-related oscillations (EROs)GIRK2KCNJ6Monetary gambling taskReward processingTheta power

More Related Videos

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

12.4K
Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
11:33

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Published on: March 12, 2013

13.8K

Related Experiment Videos

Last Updated: Mar 9, 2026

Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG
09:35

Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG

Published on: March 10, 2017

9.7K
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

12.4K
Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
11:33

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Published on: March 12, 2013

13.8K

Area of Science:

  • Neuroscience
  • Genetics
  • Cognitive Science

Background:

  • Event-related oscillations (EROs) are heritable neurocognitive measures used in genetic research.
  • A prior genome-wide association study (GWAS) linked theta EROs during visual tasks to KCNJ6 gene SNPs, including rs702859 encoding GIRK2.
  • GIRK2 is a potassium channel crucial for regulating neuronal network excitability.

Purpose of the Study:

  • To investigate the effect of the KCNJ6 SNP (rs702859) on theta EROs during reward processing.
  • To explore genetic influences on neuronal circuits involved in evaluating monetary gains and losses.

Main Methods:

  • Studied 1601 adolescent and young adult offspring (17-25 years) from the COGA prospective study.
  • Analyzed theta ERO power (3.5-7.5Hz, 200-500ms post-stimulus) across different genotype groups (AA, AG, GG) for the KCNJ6 rs702859 SNP.
  • Compared EROs during a monetary gambling task involving both loss and gain conditions.

Main Results:

  • Theta ERO power in central and parietal regions increased with the dose of the minor allele (A) of the KCNJ6 SNP (rs702859).
  • This effect was observed in both loss and gain conditions during the reward processing task.
  • Increased theta power correlated with the minor allele dose, suggesting more efficient cognitive processing.

Conclusions:

  • Variations in the KCNJ6 SNP (rs702859) significantly influence theta oscillations in posterior brain regions during reward evaluation.
  • Findings highlight a genetic contribution to reward processing via modulation of neuronal circuits.
  • Further research is needed to clarify if these genetic effects represent protective factors or indicators of delayed brain maturation.