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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Oral Drug Delivery Systems: Continuous-Release Systems01:26

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Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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Related Experiment Video

Updated: Mar 9, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
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Sustained tobramycin release from polyphosphate double network hydrogels.

Dwight D Lane1, Amber K Fessler1, Seungah Goo2

  • 1Department of Bioengineering, University of Utah, 20 S. 2030 East, Salt Lake City, UT 84112, USA.

Acta Biomaterialia
|December 21, 2016
PubMed
Summary
This summary is machine-generated.

This study developed polyphosphate hydrogels for sustained local antibiotic delivery. These hydrogels effectively eradicated Pseudomonas aeruginosa biofilms and show promise for preventing infections.

Keywords:
AminoglycosideBiofilmDouble network hydrogelLocal drug deliveryPolyelectrolytePseudomonas aeruginosaSustained releaseTobramycin

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Area of Science:

  • Biomaterials Science
  • Infectious Diseases
  • Drug Delivery Systems

Background:

  • Systemic antibiotic administration has drawbacks; local delivery offers an alternative.
  • Biofilm infections are often resistant to systemic antibiotics.
  • Sustained local antibiotic release can improve treatment efficacy.

Purpose of the Study:

  • To develop and evaluate a novel hydrogel for sustained local delivery of tobramycin.
  • To assess the hydrogel's efficacy in treating Pseudomonas aeruginosa biofilms.
  • To investigate the impact of physiological ions on drug release.

Main Methods:

  • Fabrication of a double network hydrogel using polyphosphate and polyacrylamide.
  • Loading the hydrogel with tobramycin at high concentrations (200mg/ml).
  • In vitro release studies and biofilm eradication assays in a flow cell bioreactor.

Main Results:

  • Hydrogels demonstrated sustained tobramycin release above the minimal bactericidal concentration for over 50 days.
  • Complete eradication of established P. aeruginosa biofilms within 72 hours was achieved.
  • Physiological concentrations of Mg2+ and Ca2+ doubled cumulative drug release over 60 days.

Conclusions:

  • Polyphosphate hydrogels provide effective sustained local delivery of tobramycin.
  • These hydrogels are promising for preventing and treating P. aeruginosa infections, especially those in biofilms.
  • The material demonstrates potential for localized post-operative infection prevention.