Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

7.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
7.9K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

690
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
690
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

10.1K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.1K
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

561
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
561
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

1.1K
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modular in vivo antibody-ADC click to reverse drug resistance in tumours.

Nature·2026
Same author

Targeting Fibroblast Activation Protein with [177Lu]Lu-FAP-2286 in Patients with Advanced Solid Tumors in the Phase I LuMIERE Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

<sup>18</sup>F-FDG -PET/CT in cardiac sarcoidosis: Diagnosis, therapy monitoring, and future directions.

Seminars in nuclear medicine·2026
Same author

Response to "Considerations in Imaging-Based Assessment of Steatotic Liver Disease to Enhance Harmonization, Longitudinal Interpretation, and Clinical Implementation".

Korean journal of radiology·2026
Same author

CD8 PET imaging with [<sup>89</sup>Zr]Zr-berdoxam-crefmirlimab in patients with solid tumors: the Phase II iCorrelate study.

Journal for immunotherapy of cancer·2026
Same author

Pediatric thyroid cancer lung metastases and RAI: long-term results.

Journal of pediatric endocrinology & metabolism : JPEM·2026

Related Experiment Video

Updated: Mar 9, 2026

Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

15.5K

Indeterminate Findings on Oncologic PET/CT: What Difference Does PET/MRI Make?

Tyler J Fraum1, Kathryn J Fowler1, Jonathan McConathy1

  • 1Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus Box 8131, Saint Louis, MO 63110 USA.

Nuclear Medicine and Molecular Imaging
|December 21, 2016
PubMed
Summary

Positron emission tomography/magnetic resonance imaging (PET/MRI) improved diagnostic certainty for indeterminate findings on positron emission tomography/computed tomography (PET/CT) scans. This advanced imaging technique can reduce the need for additional diagnostic studies in oncology patients.

Keywords:
Clinical oncologyMagnetic resonance imagingMultimodal imagingPositron emission tomographyWhole-body imaging

More Related Videos

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
09:18

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

668
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.6K

Related Experiment Videos

Last Updated: Mar 9, 2026

Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

15.5K
Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
09:18

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

668
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.6K

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology
  • Medical Imaging

Background:

  • Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) is a standard for cancer staging and treatment assessment.
  • PET/CT is often complemented by MRI for improved local tumor invasion assessment and detection in organs with high background FDG uptake.
  • PET/MRI offers potential to enhance PET imaging by increasing reader confidence and reducing the need for subsequent investigations.

Purpose of the Study:

  • To evaluate the efficacy of FDG-PET/MRI in clarifying indeterminate findings from clinical FDG-PET/CT studies.
  • To assess the diagnostic accuracy and impact of PET/MRI on clinical decision-making compared to PET/CT.

Main Methods:

  • 190 oncology patients underwent sequential whole-body PET/CT and PET/MRI using the same FDG administration.
  • PET/CT reports were reviewed, identifying 31 patients (16%) with indeterminate findings.
  • Two readers evaluated both PET/CT and PET/MRI studies for these 31 patients, correlating interpretations with follow-up data.

Main Results:

  • PET/MRI provided more definitive interpretations in 18 of 31 indeterminate cases, differentiating infection/inflammation from malignancy (15/18) and improving lesion localization/characterization.
  • Superior soft tissue contrast and diffusion-weighted imaging on MRI contributed to enhanced reader certainty.
  • In 12 cases with a standard of reference, definitive PET/MRI interpretations were accurate, avoiding 6 additional diagnostic studies.

Conclusions:

  • Indeterminate PET/CT findings can lead to equivocal results and necessitate further diagnostic tests.
  • PET/MRI demonstrates potential to reduce indeterminate findings, improve tumor staging, FDG activity localization, and lesion characterization.
  • Whole-body PET/MRI offers diagnostic advantages over PET/CT, leading to more definitive interpretations and potentially improving overall clinical utility.