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Related Concept Videos

Mucosal Barrier of the Stomach01:25

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The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
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Physiology of Enteric Nervous System and Gut Health01:05

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The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Related Experiment Video

Updated: Mar 9, 2026

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
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Abnormal Barrier Function in Gastrointestinal Disorders.

Ricard Farré1,2, María Vicario3,4,5

  • 1Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.

Handbook of Experimental Pharmacology
|December 21, 2016
PubMed
Summary
This summary is machine-generated.

The intestinal barrier

Keywords:
Barrier functionEnteric nervous systemEpithelial integrityIntestinal permeabilityParacellular transportTight junctionsTransport routes

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Area of Science:

  • Gastroenterology and immunology
  • Gut-brain axis research

Background:

  • The intestinal barrier's function is critical for health, with its deregulation linked to digestive and non-digestive diseases.
  • It limits antigen entry while enabling nutrient absorption, involving epithelium, immunity, and neural activity.

Purpose of the Study:

  • To elucidate the mechanisms controlling intestinal barrier function.
  • To highlight the role of barrier dysfunction in functional gastrointestinal disorders (FGIDs).

Main Methods:

  • Review of current research on intestinal barrier physiology and pathology.
  • Focus on structural and functional alterations in FGIDs like functional dyspepsia (FD) and irritable bowel syndrome (IBS).

Main Results:

  • Evidence suggests structural gut alterations in subsets of FGIDs.
  • These alterations correlate with increased intestinal permeability, mucosal inflammation, and neural activation.

Conclusions:

  • The concept of FGIDs lacking structural abnormalities is evolving.
  • Intestinal barrier dysfunction, involving inflammation and neural changes, is a key factor in FGIDs.