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Microwave-Assisted Development of Orally Disintegrating Tablets by Direct Compression
Kishor V Kande1, Darsheen J Kotak1, Mariam S Degani1
1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence (Maharashtra), N.P. Marg, Matunga (E), Mumbai, 400019, Maharashtra, India.
Microwave-assisted development of orally disintegrating tablets (ODTs) using direct compression offers a simple, scalable technology. This method enhances tablet hardness and ensures rapid disintegration for improved drug delivery.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Drug Delivery Systems
Background:
- Orally disintegrating tablets (ODTs) require simple manufacturing to achieve both mechanical strength and rapid disintegration.
- Direct compression is a preferred tableting method due to its simplicity and cost-effectiveness.
- Developing ODTs with optimal properties using straightforward techniques remains a challenge.
Purpose of the Study:
- To evaluate microwave-assisted technology for developing ODTs via direct compression.
- To optimize ODT formulations for mechanical strength and rapid disintegration.
- To develop palatable Lamotrigine (LMG) ODTs with enhanced dissolution and stability.
Main Methods:
- Placebo ODTs were prepared using direct compression with mannitol, lactose, super disintegrants, and lubricants.
- Tablets underwent humidification followed by microwave irradiation (490 W, 5 min).
- Lamotrigine ODTs were developed using a 2^3 factorial design, incorporating beta-cyclodextrin for solubilization and taste-masking agents.
Main Results:
- Microwave irradiation significantly increased placebo ODT hardness (>5 kg/cm²) and decreased disintegration time (<60 s).
- Optimized LMG ODTs exhibited hardness >5 kg/cm², disintegration time <30 s, and rapid drug dissolution.
- Beta-cyclodextrin complexation improved LMG dissolution and taste masking; flavors further enhanced palatability, confirmed by electronic tongue analysis.
Conclusions:
- Microwave-assisted direct compression provides a practical and scalable method for producing robust ODTs.
- The developed ODTs demonstrate improved mechanical properties, rapid disintegration, and enhanced drug dissolution.
- This technology represents a significant advancement for ODT manufacturing, ensuring drug stability and palatability.
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