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Updated: Mar 9, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

Keloid progression: a stiffness gap hypothesis.

Chenyu Huang¹, Longwei Liu², Zhifeng You²

¹Department of Dermatology Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.

International Wound Journal

|December 21, 2016

Summary

This summary is machine-generated.

Keloids are skin disorders where a large stiffness gap between extracellular matrix (ECM) and cells drives progression. This mechanobiology insight may lead to new keloid treatments.

Keywords:

Extracellular cell matrix stiffness Keloid Mechanobiology Mechanoresponsiveness Scar pathology

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Last Updated: Mar 9, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

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Area of Science:

Dermatology
Biophysics
Mechanobiology

Background:

Keloids are fibroproliferative skin disorders with characteristic horizontal progression and recurrence.
Their etiology involves genetic, environmental, and metabolic factors, but mechanical influences are increasingly recognized.

Purpose of the Study:

To propose a novel hypothesis explaining keloid progression based on the mechanical properties of the extracellular matrix (ECM) and cellular components.
To investigate the role of the stiffness gap between ECM and cells in keloid development and recurrence.

Main Methods:

The study introduces the 'stiffness gap hypothesis,' linking ECM and cellular stiffness to keloid pathogenesis.
It analyzes clinical observations, including keloid shape and progression patterns, in the context of mechanobiology.

Main Results:

An enlarged stiffness gap between ECM and cellular stiffness potentiates keloid progression.
Imbalances in ECM and cell stiffness, along with decompensation of cushioning factors (prestress, topology), aggravate keloid development.
The hypothesis explains keloid morphology, horizontal growth, and post-surgical recurrence.

Conclusions:

The stiffness gap hypothesis provides a mechanobiological framework for understanding keloid progression.
This framework may guide the development of novel mechanotherapeutic strategies for keloid treatment.