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Combined liver and pancreas procurement with Belzer-UW solution
H W Sollinger1, W B Vernon, A M D'Alessandro
1Department of Surgery, University of Wisconsin School of Medicine, Madison.
Surgery
|October 1, 1989
Summary
Belzer-UW solution enables successful multiorgan procurement, significantly improving graft availability for transplantation. This method ensures excellent graft function for abdominal organs like kidneys, pancreas, and livers.
Area of Science:
- Transplantation immunology
- Organ preservation
- Surgical innovation
Background:
- Graft availability is a critical bottleneck in organ transplantation.
- The Belzer-UW solution is a widely used preservation fluid for organs.
Purpose of the Study:
- To evaluate the efficacy of Belzer-UW solution in multiorgan procurement.
- To assess graft function and survival rates following transplantation.
Main Methods:
- Utilized Belzer-UW solution for in situ aortic flush and ex vivo cold storage.
- Procured multiple organs (pancreas, liver, kidney, heart) from 20 donors.
- Monitored preservation times and employed machine perfusion for isolated kidneys.
Main Results:
- Procured 20 pancreata, 20 livers, 39 kidneys, and 10 hearts.
- Achieved excellent graft survival rates: 100% for kidney and pancreas, 93.3% for isolated kidney, and 78.5% for liver at the University of Wisconsin.
- 84 out of 89 procured organs were functioning at 1 month post-transplant, including those sent to other centers.
Conclusions:
- Belzer-UW solution is highly effective for multiorgan procurement.
- This approach leads to excellent graft function and survival across various abdominal organs.
- Multiorgan procurement with Belzer-UW solution addresses the limitation of graft availability.