Hippo Wades into Cancer Immunology

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Updated: Mar 9, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.8K

Thomas Gebhardt1, Kieran F Harvey2

  • 1Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia.

Developmental Cell
|December 21, 2016
PubMed

Insights

Hippo pathway inactivation paradoxically represses tumor growth by altering tumor immunogenicity. This finding suggests targeting the Hippo pathway for novel cancer immunotherapies.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • The Hippo pathway is a key regulator of organ size and a known tumor suppressor.
  • Mutations in the Hippo pathway are rarely observed in human cancers.

Purpose of the Study:

  • To investigate the paradoxical role of Hippo pathway inactivation in tumor growth.
  • To explore the potential of modulating tumor immunogenicity via the Hippo pathway for cancer therapy.

Main Methods:

  • The study by Moroishi et al. (2016) reported in Cell analyzed the effects of Hippo pathway inactivation.
  • Investigated the impact on tumor immunogenicity and growth dynamics.

Main Results:

  • Hippo pathway inactivation was found to repress tumor growth.
  • This repression is mediated by the modulation of tumor immunogenicity.

Conclusions:

  • The findings explain the infrequent occurrence of Hippo pathway mutations in cancers.
  • Hippo pathway repression emerges as a potential strategy for cancer immunotherapy.

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