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Drug-resistant tuberculosis in Naples, 2008-2013
Annalisa Del Giudice1, Alessandro Mustazzolu2, Angelo Iacobino2
1Laboratorio di Microbiologia e Virologia, Ospedali dei Colli, Naples, Italy.
Annali Dell'Istituto Superiore Di Sanita
|December 22, 2016
Summary
Multidrug-resistant tuberculosis (MDR-TB) cases rose in Naples between 2008 and 2013, primarily affecting migrants. This highlights the need for enhanced diagnosis and treatment strategies for these populations.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Drug-resistant tuberculosis (TB) poses a significant global health challenge.
- Limited data exists on drug-resistant TB trends in Southern Italy.
- Naples, Southern Italy's largest city, was the focus of this retrospective study.
Purpose of the Study:
- To investigate the prevalence and trends of drug-resistant tuberculosis in Naples from 2008 to 2013.
- To identify the demographic and geographic origins of drug-resistant TB cases.
- To assess resistance patterns to first- and second-line anti-TB drugs.
Main Methods:
- Retrospective analysis of Mycobacterium tuberculosis strains isolated between 2008 and 2013.
- Determination of drug resistance profiles for first- and second-line anti-TB medications.
- Analysis of patient origin, including Italian-born individuals and migrants.
Main Results:
- A total of 690 Mycobacterium tuberculosis strains were analyzed.
- Multidrug-resistant tuberculosis (MDR-TB) increased from 2008 to 2013.
- MDR-TB strains were predominantly found in migrants (77.4%), originating from 41 countries. Overall MDR-TB prevalence was 4.5%, with higher rates among individuals from Former Soviet Union countries (22.4%).
- High resistance rates were observed for second-line drugs, including kanamycin, ofloxacin, and capreomycin.
Conclusions:
- MDR-TB incidence in Naples showed an upward trend between 2008 and 2013.
- Migrant populations were disproportionately affected by MDR-TB.
- Intensified diagnostic and therapeutic interventions are crucial for migrant populations in Naples to control MDR-TB.
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