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Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
Published on: May 2, 2025
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Recent technological advances in pediatric brain tumor surgery.
Bassel Zebian1,2, Francesco Vergani2, José Pedro Lavrador2
1Department of Pediatric Neurosurgery, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK.
CNS Oncology
|December 22, 2016
Summary
Neuroimaging and surgical technologies have evolved significantly, enabling precise localization and maximal resection of brain tumors. Advances like MRI and endoscopy improve surgical outcomes and patient safety.
Area of Science:
- Neurosurgery
- Medical Imaging
Background:
- Early intracranial lesion localization relied on X-rays and ventriculograms since the 1880s.
- Computed tomography (CT) in 1971 and Magnetic Resonance Imaging (MRI) in 1977 revolutionized preoperative radiological localization.
- While other modalities exist, CT and MRI remain pivotal in neuroimaging.
Observation:
- Technological advancements in surgery include the microscope for magnified precision and the endoscope for minimally invasive approaches.
- Endoscopic techniques are particularly effective for treating hydrocephalus and resecting tumors in the ventricles, pituitary, and pineal regions.
- Advanced intraoperative tools such as neuronavigation, intraoperative MRI/CT, and ultrasound enhance neurosurgeons' ability to achieve maximal tumor resection safely.
Findings:
- The integration of advanced imaging and surgical technologies significantly improves the precision and safety of brain tumor resection.
- Fluorescing agents aid in defining tumor margins, while intraoperative neurophysiological monitoring protects critical brain functions.
- These combined advancements facilitate safer and more complete removal of intracranial tumors.
Implications:
- Enhanced visualization and navigation tools lead to improved surgical outcomes and reduced patient morbidity.
- Minimally invasive techniques, like endoscopy, offer new therapeutic avenues for complex brain tumors.
- Continued innovation in neurosurgical technology promises further advancements in treating neurological conditions and improving patient care.

