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[Changes in T-lymphocyte subpopulations in uveitis]
Examinations of 30 patients with uveites, carried out by the method developed by Moretta et al., have revealed changes in T-lymphocyte subpopulations, mainly of the immunodeficiency type, with the reduction of the total T-lymphocyte count in 53.3% of patients and a significant decrease of the T mu/T gamma coefficient in 60% of patients. Stage II immunodeficiency status has been diagnosed in the majority of patients with generalized and anterior uveites. Stage II T-helper deficit has been most frequently detected in uveites coursing for 1-3 years with an exudative hemorrhagic component. The detection of the types and variant of immunoregulatory lymphocyte disorders helps choose the treatment strategy, including immunocorrecting drugs.
Examinations of 30 patients with uveites, carried out by the method developed by Moretta et al., have revealed changes in T-lymphocyte subpopulations, mainly of the immunodeficiency type, with the reduction of the total T-lymphocyte count in 53.3% of patients and a significant decrease of the T mu/T gamma coefficient in 60% of patients. Stage II immunodeficiency status has been diagnosed in the majority of patients with generalized and anterior uveites. Stage II T-helper deficit has been most frequently detected in uveites coursing for 1-3 years with an exudative hemorrhagic component. The detection of the types and variant of immunoregulatory lymphocyte disorders helps choose the treatment strategy, including immunocorrecting drugs.