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Related Experiment Video

Updated: Mar 9, 2026

Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy
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Heparinase-modified thromboelastography in cats.

Benoît Cuq1, Marilyn E Dunn1, Christian Bédard2

  • 1Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St Hyacinthe, QC, Canada.

Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001)
|December 22, 2016
PubMed
Summary
This summary is machine-generated.

Heparinase effectively reverses heparin

Keywords:
felinehemostasisheparinviscoelastic coagulation analysis

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Area of Science:

  • Veterinary Hematology
  • Coagulation Science
  • Diagnostic Hemostasis

Background:

  • Evaluating feline hemostasis is difficult in patients on anticoagulants.
  • Stopping anticoagulants risks thrombotic events.
  • Heparinase may enable testing without discontinuing anticoagulants.

Purpose of the Study:

  • To assess if heparinase can reverse heparin's effects in feline blood samples.
  • To determine if TEG can accurately measure hemostasis in heparinized cats.

Main Methods:

  • Tissue factor (TF)-activated thromboelastography (TEG) was used on 19 feline blood samples.
  • Blood was tested with and without unfractionated heparin (0.2 U/mL).
  • TEG assays were performed using standard and heparinase-coated cups.

Main Results:

  • No significant differences in TEG variables (R, k, α-angle, MA) were found in non-heparinized blood using standard vs. heparinase cups.
  • Heparinized blood in standard cups showed altered TEG variables (increased R/k, decreased α-angle/MA) compared to heparinase cups.
  • Heparinized blood in heparinase cups yielded TEG results comparable to non-heparinized blood.

Conclusions:

  • Heparinase-modified TEG successfully reverses heparin's anticoagulant effects in feline blood.
  • This method allows for accurate hemostatic evaluation in cats receiving heparin therapy.