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Updated: Mar 9, 2026

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
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The Dynamic Behavior of the P2X4 Ion Channel in the Closed Conformation

Gustavo Pierdominici-Sottile1, Luciano Moffatt2, Juliana Palma1

  • 1Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, CONICET, Buenos Aires, Argentina.

Biophysical Journal
|December 22, 2016
PubMed
Summary

Molecular dynamics simulations reveal P2X4 receptor opening. ATP binding resolves impediments in the closed state, enabling channel pore formation through interchain movements.

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