Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 9, 2025

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
09:20

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Published on: October 4, 2019

5.7K

From static to animated: Measuring mechanical forces in tissues.

Celeste M Nelson1,2

  • 1Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544.

The Journal of Cell Biology
|December 23, 2016
PubMed
Summary

New techniques will soon measure cell-generated mechanical forces in living tissues. This breakthrough will reveal cells

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patterns of mitochondrial ATP predict tissue folding.

Science advances·2026
Same author

Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer.

APL bioengineering·2026
Same author

Biophysical processes of morphogenesis in lizard lungs.

Developmental dynamics : an official publication of the American Association of Anatomists·2025
Same author

Biophysical mechanisms of morphogenesis in lizard lungs.

bioRxiv : the preprint server for biology·2025
Same author

Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.

Development (Cambridge, England)·2024
Same author

Relatively Rare Populations of Invasive Cells Drive Progression of Heterogeneous Tumors.

Cellular and molecular bioengineering·2024

Area of Science:

  • Cell biology
  • Biophysics
  • Mechanobiology

Background:

  • Cells are physical entities that generate mechanical forces.
  • Cell migration and tissue organization are driven by these forces.
  • Understanding these forces is crucial for comprehending cellular functions.

Purpose of the Study:

  • To introduce novel techniques for measuring cell-generated forces.
  • To enable in vivo force measurements within intact tissues.
  • To advance the understanding of cell dynamics and tissue development.

Main Methods:

  • Development of advanced force-sensing technologies.
  • Application of these techniques in live, intact biological tissues.
  • In vivo mechanical analysis of cellular interactions.

Main Results:

  • Successful measurement of cell-generated mechanical forces in vivo.
  • Illumination of the dynamic mechanical interactions of cells within tissues.
  • Potential to reveal previously unobserved cellular behaviors.

Conclusions:

  • New techniques offer unprecedented insights into cell mechanics.
  • In vivo force measurements will transform cell biology.
  • This research redefines our perception of cellular dynamics and tissue engineering.

More Related Videos

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.8K
Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy
11:10

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy

Published on: August 28, 2011

23.3K

Related Experiment Videos

Last Updated: Nov 9, 2025

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
09:20

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Published on: October 4, 2019

5.7K
Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.8K
Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy
11:10

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy

Published on: August 28, 2011

23.3K