Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MMP9 Genotype and Systemic T-Cell Subsets Correlate With Structural and Functional Outcomes in Neovascular Age-Related Macular Degeneration.

Investigative ophthalmology & visual science·2026
Same author

Exudative Diabetic-Radiation Retinopathy with Lipemia Retinalis Mimicking Cytomegalovirus Retinitis.

Retinal cases & brief reports·2026
Same author

Deconstructing White Dot Syndromes-Multimodal Imaging in Uveitis (MUV) Taskforce: Report 11.

American journal of ophthalmology·2026
Same author

Diabetic Retinopathy Severity on Ultra-Widefield Fluorescein Angiography versus Color Photography and Association with Risk of Disease Worsening.

Ophthalmology science·2026
Same author

FOXC1 Duplications-New Mutations and Clinical Features in an Old Glaucoma Gene.

JAMA ophthalmology·2026
Same author

Oral Tonabersat Connexin-43 Modulator for Diabetic Macular Edema with Good Vision (DRCR Retina Network Protocol AN).

Ophthalmology science·2026

Related Experiment Video

Updated: Mar 9, 2026

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
11:38

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

14.0K

MMP19 expression in the human optic nerve.

Kathleen R Chirco1, Ralph J Hazlewood2, Kathy Miller1

  • 1Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA; Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, IA.

Molecular Vision
|December 23, 2016
PubMed
Summary
This summary is machine-generated.

Matrix metalloproteinase 19 (MMP19) is abundant in the optic nerve head, particularly in the septa. Its peripheral localization suggests a role in optic disc structural integrity and potential involvement in cavitary optic disc anomaly (CODA) and glaucoma.

More Related Videos

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

20.3K
Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity
07:11

Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity

Published on: September 19, 2025

1.2K

Related Experiment Videos

Last Updated: Mar 9, 2026

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
11:38

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

14.0K
Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

20.3K
Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity
07:11

Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity

Published on: September 19, 2025

1.2K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Molecular Biology

Background:

  • Glaucoma is characterized by optic nerve head excavation, but the underlying mechanisms are unclear.
  • Cavitary optic disc anomaly (CODA) presents with excavated optic discs similar to glaucoma.
  • A copy number variation upstream of matrix metalloproteinase 19 (MMP19) was identified in a CODA pedigree.

Purpose of the Study:

  • To characterize the localization of MMP19 within the human optic nerve.

Main Methods:

  • Western blot analysis of human optic nerve, retina, and RPE/choroid.
  • Immunohistochemistry on sagittal and en face/cross sections of human optic nerves.
  • Colocalization studies with type IV collagen.

Main Results:

  • MMP19 protein was detected in the human optic nerve, retina, and RPE/choroid, with highest expression in the retina and optic nerve.
  • Immunohistochemistry localized MMP19 to the extracellular space within optic nerve septa and the arachnoid layer of the optic nerve sheath.
  • MMP19 exhibited a peripheral-to-central gradient in optic nerve cross sections.

Conclusions:

  • Abundant MMP19 in the optic nerve head suggests a role in CODA pathology.
  • MMP19's localization implies involvement in regulating optic nerve adhesion to the scleral canal and extracellular matrix remodeling.
  • Dysregulation of MMP19 may contribute to optic disc collapse in CODA and optic disc cupping in glaucoma.