Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

43.7K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.7K
Cohesins02:20

Cohesins

5.8K
Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of...
5.8K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

602
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
602
Shearing Stress01:18

Shearing Stress

2.3K
Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
2.3K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

967
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
967
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.8K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Where are we in the diagnosis and treatment of hirsutism? A narrative review.

Reviews in endocrine & metabolic disorders·2026
Same author

Models of care on the management of women with polycystic ovary syndrome: A multicentre study.

Endocrine·2026
Same author

Investigating the relationship between thyroid replacement therapy goals status and quality of life in patients with primary hypothyroidism.

Endocrine·2026
Same author

Approach to the Patient With Traumatic Brain Injury-induced Pituitary Dysfunction.

The Journal of clinical endocrinology and metabolism·2026
Same author

Oral and gut microbiota after acromegaly treatment: prospective assessment and insights from machine learning.

Pituitary·2025
Same author

The frequency of polycystic ovary syndrome in women with prediabetes compared with normoglycemic women.

Frontiers in endocrinology·2025

Related Experiment Video

Updated: Mar 9, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.8K

Sheehan syndrome.

Züleyha Karaca1, Bashir A Laway2, Hatice S Dokmetas3

  • 1Department of Endocrinology, Erciyes University Medical School, 38039, Kayseri, Turkey.

Nature Reviews. Disease Primers
|December 23, 2016
PubMed
Summary
This summary is machine-generated.

Sheehan syndrome, or postpartum hypopituitarism, is pituitary gland damage from severe postpartum hemorrhage. This can lead to hormone deficiencies, with symptoms appearing years later.

More Related Videos

Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
06:20

Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

Published on: December 5, 2020

2.9K
Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

1.1K

Related Experiment Videos

Last Updated: Mar 9, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.8K
Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
06:20

Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

Published on: December 5, 2020

2.9K
Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

1.1K

Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Pathophysiology

Background:

  • Sheehan syndrome is pituitary necrosis caused by postpartum hemorrhage (PPH).
  • Predisposing factors include small sella turcica, vasospasms, thrombosis, and potential autoimmunity.
  • It's a significant cause of hypopituitarism, especially in developing nations.

Approach:

  • Clinical manifestations and PPH history are key diagnostic indicators.
  • Hormone levels and stimulation tests confirm suspected cases.
  • Management focuses solely on hormone replacement therapy.

Key Points:

  • Growth hormone and prolactin are most commonly affected, followed by gonadotropins.
  • Thyroid-stimulating hormone and adrenocorticotropic hormone secretion are impacted in severe cases.
  • Symptoms range from lactation failure to adrenal crisis, often manifesting years post-delivery.

Conclusions:

  • Sheehan syndrome incidence correlates with PPH occurrence and management.
  • While rare in developed countries, it remains a critical health concern globally.
  • Hormone replacement therapy is the current standard of care.