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Noise Induces Hopping between NF-κB Entrainment Modes
Mathias Heltberg1, Ryan A Kellogg2, Sandeep Krishna3
1Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark.
Cell Systems
|December 24, 2016
Summary
Noise and oscillations influence biological processes like nuclear factor κB (NF-κB) activity. This study reveals that noise-induced "cellular mode-hopping" in NF-κB dynamics allows for timed gene expression.
Area of Science:
- Cellular dynamics
- Systems biology
- Molecular biology
Background:
- Biological processes are influenced by oscillations and noise.
- The specific effects of both on the transcription factor nuclear factor κB (NF-κB) activity remain unclear.
Purpose of the Study:
- To investigate how oscillations and noise affect NF-κB activity.
- To understand the phenomenon of "cellular mode-hopping" observed in NF-κB oscillations.
Main Methods:
- Experimental observation of NF-κB oscillations entrained by periodic tumor necrosis factor (TNF) inputs.
- Comparison of stochastic simulations with deterministic simulations of NF-κB dynamics.
- Analysis of NF-κB behavior within and outside the chaotic regime of parameter space.
Main Results:
- NF-κB exhibits "cellular mode-hopping" between frequency modes when entrained by periodic TNF inputs.
- Noise facilitates mode-hopping across all dynamic regimes.
- Experimental mode-hopping patterns align with noise-induced hopping outside the chaotic regime, differing from chaotic dynamics.
Conclusions:
- Noise-induced mode-hopping is a key mechanism in NF-κB dynamics.
- This phenomenon may enable temporal control of gene expression by different NF-κB-dependent genes.
- Cellular mode-hopping provides a novel perspective on how cells regulate gene expression in response to external stimuli.
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