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A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
Published on: October 17, 2016
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Development of polymeric functionally graded scaffolds: a brief review
Roberto Scaffaro1, Francesco Lopresti1, Andrea Maio1
1Department of Civil, Environmental, Aerospace, Materials Engineering, RU INSTM, University of Palermo, Palermo - Italy.
Journal of Applied Biomaterials & Functional Materials
|December 24, 2016
Summary
Functionally graded scaffolds (FGSs) mimic native tissue properties with tailored gradients. This review overviews common fabrication strategies for these advanced regenerative medicine scaffolds.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Growing interest in multilayer scaffolds for mimicking native tissue functions.
- Functionally Graded Scaffolds (FGSs) offer tunable biological and mechanical properties.
- Current limitations in traditional scaffolds necessitate advanced fabrication approaches.
Purpose of the Study:
- To provide an overview of common strategies for preparing Functionally Graded Scaffolds (FGSs).
- To highlight fabrication techniques for customizing scaffold properties in space.
- To address the need for advanced scaffolds in regenerative medicine.
Main Methods:
- Review of various fabrication technologies for FGSs.
- Discussion of strategies for creating gradual changes in scaffold properties (physical, mechanical, biochemical).
- Categorization of FGSs into bilayered, multilayered, or continuously graded structures.
Main Results:
- FGSs can be fabricated using diverse, often combined, technologies.
- Scaffolds can exhibit distinct layers or continuous property gradients.
- Different approaches present unique advantages and disadvantages for FGS fabrication.
Conclusions:
- FGSs represent a promising approach to overcome limitations of current treatments.
- Tailored fabrication strategies are crucial for optimizing regenerative performance.
- This review focuses on FGS preparation methods, distinct from application-focused reviews.
